Synthesis and Antiarrhythmic Activity of 2,5-Disubstituted 2,3-Dihydro-1,2,5-benzothiadiazepin-4(5H)-one 1,1-Dioxides
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概要
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A series of 2,5-disubstituted 2,3-dihydro-1,2,5-benzothiadiazepin-4(5H)-one 1,1-dioxide derivatives were prepared and evaluated for the antiarrhythmic effect on ouabain-induced arrhythmias in guinea pigs. Most of the synthesized compounds showed the antiarrhythmic activity in this primary screening system. Some of the compounds with 2-(N, N-dimethylamino)ethyl, 2-(pyrrolidin-1-yl)ethyl and 2-oxo-2-(morpholin-4-yl)ethyl moieties on the 5-position of 1,2,5-benzothiadiazepin-4(5H)-one 1,1-dioxide exhibited a potent antiarrhythmic activity. THe structure-activity relationship of these compounds was discussed.
- 社団法人日本薬学会の論文
- 1992-09-25
著者
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小川 和男
Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,
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小川 和男
Faculty Of Pharmaceutical Sciences Kanazawa University
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小川 和男
Hanno Research Center, Taiho Pharmaceutical Co., Ltd.,
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松下 洋一
Hanno Research Center, Taiho Pharmaceutical Co., Ltd.,
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松下 洋一
Research Institute Taiho Pharmaceutical Co. Ltd. :(present Address)department Of Industrial Chemistr
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