Studies on Hypolipidemic Agents. III. Synthesis and Esterase-Inhibitory Activity of ω-Cycloalkyl-2-oxoalkyl Arenesulfonates(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
Various ω-cycloalkyl-2-oxoalkyl arenesulfonates were synthesized and evaluated for esterase- and chymotrypsin-inhibitory activities and hypolipidemic activity. Among the tested compounds, 2-oxoalkyl arenesulfonates(4,8 and 13) having a cyclohexyl substituent at the terminus of the alkyl chain exhibited considerable esterase-inhibitory activity, and several compounds among 4 and 8 also exhibited potent hypolipidemic action. The structure-activity relationships of these compounds are discussed.
- 社団法人日本薬学会の論文
- 1987-06-25
著者
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寺田 忠史
Hanno Research Center, Taiho Pharmaceutical Co., Ltd.,
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小川 和男
Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,
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寺田 忠史
Hanno Research Center Taiho Pharmaceutical Co. Ltd.
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小川 和男
Research Institute, Taiho Pharmaceutical Co., Ltd.
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寺田 忠史
Research Institute, Taiho Pharmaceutical Co., Ltd.
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小川 和男
Faculty Of Pharmaceutical Sciences Kanazawa University
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村中 義幸
Research Institute, Taiho Pharmaceutical Co., Ltd.
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浜川 寿博
Research Institute, Taiho Pharmaceutical Co., Ltd.
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藤井 節郎
Research Institute, Taiho Pharmaceutical Co.. Ltd.
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村中 義幸
Research Institute Taiho Pharmaceutical Co.. Ltd.
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浜川 寿博
Research Institute Taiho Pharmaceutical Co.. Ltd.
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