Syntheses of N, N, 3- and N, N, 9-Trialkyladenines by Alkylation of N, N-Dialkyladenines

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概要

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• Alkylations of N, N-dimethyl-(Ia) and N, N-diethyladenine (Ib) with methyl iodide, ethyl iodide, and benzyl bromide in N, N-dimethylacetamide in the presence of potassium carbonate gave the corresponding N, N, 9-trialkyladenines (II) in 54-74% yields, as well as minor amounts of N, N, 3-trialkyladenines (III). The alkylation of I without base gave the latter compounds (III) in 76-90% yields.

• 公益社団法人日本薬学会の論文
• 1980-06-25

著者

• 小川 和男

  Tokushima Research Center, Pharmacokinetics Research Lab., Taiho Pharmaceutical Co., Ltd.,

• 小川 和男

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 板谷 泰助

  金沢大学薬学部

• 松本 浩郎

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 松本 浩郎

  Central Research Institute, Nissan Chemical Ind. Ltd.

• 松本 浩郎

  Central Research Institute Nissan Chemical Ind. Ltd.

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