フェニルアラニン転移リボ核酸超修飾ヌクレオシドの合成をめぐって
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This review highlights the first total synthesis of (αS, βS)-β-hydroxywybutosine, the identity of which was established with fluorescent nucleoside isolated from rat liver tRNA^<Phe>. Three general prerequisites for the synthesis of the target are emphasized: construction of new 9-β-D-ribofuranosyl-3-methylpurines ; the first syntheses of optically active γ-aryl-α, β-unsaturated amino acids; and a new method for hydrogenolysis of glycols through their cyclic carbonates to give the γ-aryl-β-hydroxy amino acid derivatives. The mechanism for the formation of cyclic carbonates from reactions of glycols with (COC1)_2 and highly selective preparation of the cyclic oxalates are also described.
- 公益社団法人日本薬学会の論文
- 2003-05-01
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関連論文
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- Purines. LXVII. An Alternative Synthesis of Adenine 7-Oxide : N-Oxidation of the Adenine Ring Utilizing Blocking/Deblocking at the 1-Position
- Purines. LXVI. Adenine 7-Oxide : Its Synthesis, Chemical Properties, and X-ray Molecular Structure
- Purines. LII. Synthesis and Biological Evaluation of 8-Methylguanine 7-Oxide and Its 9-Arylmethyl Derivatives
- Purines. LI. Synthesis and Biological Activity of Hypoxanthine 7-N-Oxide and Related Compounds
- Purines. L. Synthesis and Antileukemic Activity of the Antibiotic Guanine 7-Oxide and Its 9-Substituted Derivatives
- FORMATION OF CYCLIC CARBONATES IN THE REACTIONS OF 1,2-GLYCOLS WITH OXALYL CHLORIDE
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- Synthesis of 5-(Methylamino)-1-β-D-ribofuranosylimidazole-4-carboxamide, a Synthetic Intermediate for 3-Methyl-9-β-D-ribofuranosylpurines
- An Improved Procedure for the Synthesis of 1-Alkyl-5-(alkylamino)-imidazole-4-carboxamides, Synthetic Intermediates for 3,9-Dialkylpurine Derivatives
- Synthesis of N, N, 3,9-Tetraalkyladeninium Halides by Alkylations of N, N, 3- and N, N, 9-Trialkyladenines
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- フェニルアラニン転移リボ核酸超修飾ヌクレオシドの合成をめぐって
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- 不老不死の薬(薬学第二世紀の出発点に立って)