Synthesis of 5-(Methylamino)-1-β-D-ribofuranosylimidazole-4-carboxamide, a Synthetic Intermediate for 3-Methyl-9-β-D-ribofuranosylpurines

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概要

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• Treatment of 2', 3', 5'-tri-O-benzoyl-N, N-dimethyladenosine (2c) with methyl iodide in AcNMe_2 gave the 3-methyl derivative (3c) as a sole product. Alkaline hydrolysis of 3c afforded the title imidazolecarboxamide (4a), whose hydroxy groups were acetylated selectively with Ac_2O-pyridine. Similar methylation of 2', 3', 5'-tri-O-benzyl-N, N-dimethyladenosine (2d) followed by alkaline hydrolysis provided 2', 3', 5'-tri-O-benzyl-4a (4d) in good yield.

• 公益社団法人日本薬学会の論文
• 1982-01-25

著者

• 板谷 泰助

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 渡辺 朝子

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 板谷 泰助

  金沢大学薬学部

• 松本 浩郎

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 松本 浩郎

  Central Research Institute, Nissan Chemical Ind. Ltd.

• 松本 浩郎

  Central Research Institute Nissan Chemical Ind. Ltd.

関連論文

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