Sythesis and Crystal Structure of Optically Active 2-[Benzyl(phenyl)amino]ethyl 5-(5,5-Dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ-105)
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概要
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(S)-2-[Benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl -2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate ((S)-NZ-105) and R isomer were synthesized throuth the fractional crystallization of (S)-2-Methoxy-2-phenylethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate. Calcium antagonism activity was found to reside in the S isomer from single crystal X-ray diffraction analysis
- 1992-09-25
著者
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瀬戸 淨智
Central Research Institute Nissan Chemical Ind. Co. Ltd.
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迫田 良三
Central Research Institute, Nissan Chemical Ind. Ltd.
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松本 浩郎
Central Research Institute, Nissan Chemical Ind. Ltd.
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迫田 良三
Central Research Institute Nissan Chemical Industries Ltd.
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松本 浩郎
Central Research Institute Nissan Chemical Ind. Ltd.
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Sakoda R
Central Research Institute Nissan Chemical Industries Ltd.
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