Transformation of 1,4-Dihydropyridine Ring of Calcium Antagonist NZ-105 into Cyclohexenone Ring
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概要
- 論文の詳細を見る
On hydrolysis of the calcium antagonist, 2-(N-benzyl-N-phenylamino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylate hydrochloride ethanol (NZ-105 1・HCl・EtOH) in 35% hydrochloric acid, the 1,4-dihydropyridine ring was transformed to a cyclohexeone ring, affording the cyclohexenonephosphonates 2 and 3.
- 1995-02-15
著者
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瀬戸 浄智
Central Research Institute Nissan Chemical Industries Ltd.
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迫田 良三
Central Research Institute Nissan Chemical Industries Ltd.
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上川路 益昌
Central Research Institute Nissan Chemical Industries Ltd.
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Sakoda R
Central Research Institute Nissan Chemical Industries Ltd.
関連論文
- Transformation of 1,4-Dihydropyridine Ring of Calcium Antagonist NZ-105 into Cyclohexenone Ring
- Sythesis and Crystal Structure of Optically Active 2-[Benzyl(phenyl)amino]ethyl 5-(5,5-Dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ-105)
- Synthesis and Biological Activities of Optical Isomers of 2-(4-Diphenylmethyl-1-piperazinyl)ethyl 5-(4,6-Dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate Dihydrochloride (NIP-101)
- Synthesis of 1,4-Dihydropyridine-5-phosphonates and Their Calcium-Antagonistic and Antihypertensive Activities : Novel Calcium-Autagonist 2-[Benzy(phenyl)amino]ethyl 5-(5,5-Dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitroph