縮合Indole-4,7-dione関連化合物の合成研究(第1報)2,3-Dichloronaphthoquinoneを出発原料とするBenz[f]indole-4,9-dione誘導体の合成
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2,3-Dichloronaphthoquinone (3) easily reacted with active methylene compounds such as dimethyl malonate, ethyl acetoacetate, diethyl oxalacetate and a Schiff base, prepared from dimethyl β-ketoglutarate and aminoacetal, in the presence of potassium succinimidate to give the corresponding substituted monochloroquinones (5a-c and 17,respectively). The chloroquinone (5a) was converted to N-substituted 2-hydroxy-3-methoxycarbonylbenz [f] indole-4,9-diones (9a-e) by the reaction with ammonia or various primary amines, and 5b was converted to N-substituted 3-ethoxycarbonyl-2-methylbenz [f] indole-4,9-diones (11a-c) in the same manner.
- 公益社団法人日本薬学会の論文
- 1979-12-25
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