Synthesis and Application of Imidazole Derivatives. Synthesis and Acyl Activation of 2-Acyl-1-methyl-1H-imidazoles(Organic,Chemical)
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概要
- 論文の詳細を見る
2-Acyl-1-methyl-1 H-imidazoles (3) were prepared in good yields by treating 1-acylpyrrolidines (5) with 2-lithio-1-methyl-1 H-imidazole (2) at -78℃. The acyl group of 3 was very stable under various severe conditions, but 2-benzoylimidazole (3a) was gradually hydrolyzed by heating with 1.3_N NaOH to produce benzoic acid and 1-methyl-1 H-imidazole. Acyl activation of 3 was performed by direct quaternization of 3 with iodomethane or dimethyl sulfate or more successfully by quaternization of the corresponding O-trimethylsilylated gcm-cyanohydrin (11) with dimethyl sulfatts.
- 公益社団法人日本薬学会の論文
- 1986-12-25
著者
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太田 俊作
Kyoto Pharmaceutical University
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岡本 正夫
Kyoto Pharmaceutical University
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原田 鈴美
Kyoto Pharmaceutical University
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太田 俊作
京都薬科大学薬学部
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早川 聡史
Kyoto Pharmaceutical University
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森脇 浩樹
Kyoto Pharmaceutical University
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太田 俊作
Kyoto College Of Pharmacy
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