Synthesis and Application of Imidazole Derivatives. : Synthesis of (1-Methyl-1H-imidazol-2-yl)methanol Derivatives and Conversion into Carbonyl Compounds(Organic,Chemical)
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概要
- 論文の詳細を見る
(1-Methyl-1H-imidazol-2-yl)methanol derivatives (4 and 7) were prepared by treatingcarbonyl compounds with 2-lithio-1-methyl-1H-imidazole (2) or by treating 2-acyl-1H-imidazoles (3) with organometallic reagents or sodium borohydride. The alcohols (4 and 7) were convertible into the carbonyl compounds via the corresponding quaternary salts (8 and 10). The stable (1-methyl-1H-imidazol-2-yl)methanol system, R-C(OH)-C=N-CH=CH-NCH_3, can be regarded as a masked form of the carbonyl group as well as a synthon of the group.
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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太田 俊作
Kyoto Pharmaceutical University
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岡本 正夫
Kyoto Pharmaceutical University
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太田 俊作
京都薬科大学薬学部
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早川 聡史
Kyoto Pharmaceutical University
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西村 和子
Kyoto Pharmaceutical University
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太田 俊作
Kyoto College Of Pharmacy
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