Synthesis and Application of Triazole Derivatives. Syntehsis of 3- and 5-Acyl-1,2,4-triazoles via Lithiation of 1-Alkyl-1H-1,2,4-triazoles
スポンサーリンク
概要
- 論文の詳細を見る
N-Unsubstituted 3-acyl-1H-1,2,4-triazoles (3), and 5-acyl-1-alkyl-1H-1,2,4-triazoles (4) were synthesized by acylation of 5-lithiotriazoles with amides. The 3-position of 1-methyl-5-phenylthio-1H-1,2,4-triazole (11) was lithiated by lithium 2,2,6,6-tetramethylpiperidide, and acylation of the produced carbanion with amides followed by desulfurization with Raney nickel give the 3-acyl derivatives (5). The structural isomers, 3-acyl-4-alkyl-4H-1,2,4-triazoles (6), were prepared by N-methylation of 3.
- 公益社団法人日本薬学会の論文
- 1993-07-15
著者
-
太田 俊作
Kyoto Pharmaceutical University
-
山下 正行
Kyoto Pharmaceutical University
-
川崎 郁勇
Kyoto Pharmaceutical University
-
多田 俊治
Analytical Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
-
川崎 郁勇
京都薬大
-
多田 俊治
Analytical Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
太田 俊作
京都薬科大学薬学部
-
福野 晃久
Kyoto Pharmaceutical University
-
川端 哲郎
Analytical Research Laboratories of Fujisawa Pharmaceutical Co., Ltd.,
-
太田 俊作
Kyoto College Of Pharmacy
-
山下 正行
京都薬科大学薬学部
-
川端 哲郎
Analytical Research Laboratories Of Fujisawa Pharmaceutical Co. Ltd.
関連論文
- 簡便な腸内細菌診断法の開発
- One-Step Synthesis of 1,2,3,4-Tetrahydrobenzo[g]quinazoline-5,10-dione Derivatives from Vitamin K_3
- Ring Opening of Cyclopropanemonocarboxylates and 1,1-Cyclopropanedicarboxylates Using Samarium(II) Diiodide (SmI_2)-HMPA-THF System
- Synthesis and Application of Imidazole Derivatives. Introduction of Carbogenic Substituents into the 5-Position of 1-Methyl-1H-imidazole
- Studies on a Novel, Potent and Orally Effective Cholecystokinin A Antagonist, FK-480. Synthesis and Structure-Activity Relationships of FK-480 and Related Compounds
- Structure and Synthesis of Nectrisine, a New Immunomodulator Isolated from a Fungus
- Structure of Kifunensine, a New Immunomodulator Isolated from an Actinomycete
- K-085(30) 漢方薬による薬物相互作用 (9) : ラット小腸ミクロソームにおける CYP3A 活性に及ぼす各種漢方方剤同時添加及び単回経口投与の影響
- 81(P-77) (1-Methyl-2,5-dioxo-3-imidazolin-4-yl)amino基を有する抗腫瘍性イミダゾール系海洋天然物の全合成(ポスター発表の部)
- Introduction of Carbogenic Substituent into the 4-Position of 1-Methyl-1H-imidazole
- P-36 甘茶成分thunberginol類の合成と抗アレルギー活性 : 構造活性相関および作用様式(ポスター発表の部)
- Sweet and Bitter Diterpene-Glucosides from Leaves of Rubus suavissimus
- Synthesis and Application of Imidazole Derivatives. Synthesis of 5-Methyl-7,8,9,10-tetrahydro-5H-azepino[1,2-α]benzimidazol-7-one and Related Compounds
- A Total Synthesis of Grifolin
- Synthesis and Application of Imidazole Derivatives : Preparation of Various Diketones from 1,n-Bis(1-methyl-1H-imidazol-2-yl)alkane-1,n-diones
- Synthesis and Application of Imidazole Derivatives. : Synthesis of (1-Methyl-1H-imidazol-2-yl)methanol Derivatives and Conversion into Carbonyl Compounds(Organic,Chemical)
- An Efficient Biogenetic-Type Transformation of 3-Tertiary-hydroxyalkanoic Acids to Olefinic Compounds(Organic,Chemical)
- Synthesis and Application of Imidazole Derivatives. Synthesis and Acyl Activation of 2-Acyl-1-methyl-1H-imidazoles(Organic,Chemical)
- tert-Butyl Carboxylatesの一改良合成法について
- 縮合Indole-4,7-dione関連化合物の合成研究(第3報)γ-Amino-n-butyric Acidおよびγ-Amino-β-hydroxy-n-butyric Acidを用いるPyrrole-2-acetic Acid誘導体の合成
- Use of β-Ketocarboxylic Acids for Syntheses of 6-Substituted 4-Hydroxy-2-pyrones and Acyclic β-Diketones
- A Novel and Versatile Separation Method for Aldehydes
- Studies on the Syntheses of Condensed Indole-4,7-diones. II. Synthesis of Pyrrolo [1,2-a] indole-5,8-dione Derivatives
- 縮合Indole-4,7-dione関連化合物の合成研究(第1報)2,3-Dichloronaphthoquinoneを出発原料とするBenz[f]indole-4,9-dione誘導体の合成
- Isocarbostyril関連化合物の合成研究(第5報)2-Acylamido-3-aminoisocarbostyrilの閉環反応
- 10 メラニン生合成阻害活性天然物(±)-Linderol Aの全合成(口頭発表の部)
- RING OPENING OF CYCLOPROPANECARBOXYLATES USING SAMURIUM(II) DIIODIDE (SmI_2)-HMPA-THF SYSTEM
- Synthetic Approaches to 3-Amino-1,4-naphthoquinone-2-carboxylic Acid Derivatives and Photochemical Synthesis of Novel 1,4,5,10-Tetrahydro-5,10-dioxo-2H-naphth[2,3-d][1,3]oxazine Derivatives
- Stereochemistry of Decahydroisoquinolines and Related Compounds. VIII. Syntheses of trans-4-Hydroxy-2-methyldecahydroisoquinolines
- Interaction of Cefdinir with Iron in Aqueous Solution
- Synthetic Studies on Lycoricidine and Related Compounds. II. Total Synthesis of (±)-Lycoricidine
- Synthetic Studies on Lycoricidine and Related Compounds. I. Synthesis of 4aH-r, 2H-cis, 2-Hydroxy-8,9-methylenedioxy-2,3,4,4a-tetrahydro-6 (5H)-phenanthridone
- Isocarbostyril関連化合物の合成研究(第4報)2,3-Diaminoisocarbostyrilのアシル化
- Isocarbostyril関連化合物の合成研究(第3報)2-Methyl-3-aminoisocarbostyrilとp-置換ベンズアルデヒドの反応
- Isocarbostyril関連化合物の合成研究(第2報)2-Methyl-3-aminoisocarbostyrilとベンズアルデヒドの反応
- Isocarbostyril 関連化合物の合成研究(第1報) : 2-Methyl-3-aminoisocarbostyril と酸クロリドの反応
- Conversion of Ketone Trimethylsilylcyanohydrins to Several Types of Compounds
- SYNTHESIS OF 3-SUBSTITUTED ISOCOUMARINS AND RELATED NATURAL PRODUCTS
- Synthesis and Application of Triazole Derivatives. Syntehsis of 3- and 5-Acyl-1,2,4-triazoles via Lithiation of 1-Alkyl-1H-1,2,4-triazoles
- メラニン生合成阻害活性天然物リンデロールAの合成研究
- 83(P-14) 5(4)-Alkenylimidazole類の新規Diels-Alder二量化反応を鍵とする生理活性海洋天然物Ageliferinsの全合成研究(ポスター発表の部)
- 木本正七郎先生を偲んで
- Photo-Oxidation of 2-Methylamino-3-(1-piperidinylmethyl)-1,4-naphthoquinone
- 水溶液Hydronaphthoquinone誘導体の合成と臨床化学における過酸化水素定量への応用
- Synthesis and Application of Imidazole Deribatives. Synthesis of Pyrrolo[1,2-a]benzimidazoles and Azepino[1,2-a]benzimidazoles
- 触媒的C-H結合官能基化によるN-無保護複素環の選択的C-アリール化
- 10,11-Dihydro-5H-dibenzo[a, d]-cycloheptene誘導体の合成研究
- コレステロール抑制物質Breynin A Aglycon((+)-Breynolide)の全合成
- 合成化学における1-Acylimidazoleの新しい利用