Synthesis and Application of Imidazole Derivatives : Preparation of Various Diketones from 1,n-Bis(1-methyl-1H-imidazol-2-yl)alkane-1,n-diones
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概要
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Reaction of 1,n-bis(1-methyl-1H-imidazol-2-yl)alkane-1,n-dione (8) with an excess of Grignard reagent was examined. In the cases of n=4 and 5,precursors (14) for synthesis of various asymmetric 1,4- and 1,5-diketones (12 : R^1≠R^2), respectively, were obtained in good yields by treating 8 with an excess of methylmagnesium iodide in ether followed by trimethylsilylation. In the case of n≧8,the two carbonyl groups of 8 were both attacked by the Grignard reagent, and the products (11 : R^1=R^2=CH_3) were convertible to symmetrical diketones (12 : R^1=R^2=CH_3) in good yields. In cases of n=6 and 7,the mode of the Grignard reaction was transitional between the two types.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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太田 俊作
Kyoto Pharmaceutical University
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岡本 正夫
Kyoto Pharmaceutical University
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太田 俊作
京都薬科大学薬学部
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早川 聡史
Kyoto Pharmaceutical University
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馬場 順子
Kyoto Pharmaceutical University
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太田 俊作
Kyoto College Of Pharmacy
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