10,11-Dihydro-5H-dibenzo[a, d]cycloheptene誘導体の合成研究
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概要
- 論文の詳細を見る
Analgesic-active N-alkyl-10-hydroxy-10,5-(iminomethano)-5H, 10H-and-10-hydroxy-10,5-(iminomethano)-5H, 10H-dibenzo [a, d] cyclohepten-11-one derivatives (V) were prepared from 5-acylaminomethyl-5H-dibenzo [a, d] cycloheptene via oxidative transannular reaction-lithium aluminium hydride reduction and the transannular reaction-hydrolysis. These derivatives (V) were easily converted by treatment with alkali, alumina and heating to very interesting ring contraction products such as 3,8-(o-phenylene)-2,3,8,9-tetrahydrobenzo [d] azepin-2-one derivatives. Moreover, an interesting ring opening reaction of the derivatives (V) with acetic anhydride-alkali was examined.
- 公益社団法人日本薬学会の論文
- 1980-11-25
著者
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藤原 靖弘
京都薬大
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藤原 靖弘
Kyoto Pharmaceutical Univesity
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岡本 正夫
Kyoto Pharmaceutical University
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岡本 正夫
京都薬科大学
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尾高 宗彦
日本臓器製薬株式会社研究所
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