Use of β-Ketocarboxylic Acids for Syntheses of 6-Substituted 4-Hydroxy-2-pyrones and Acyclic β-Diketones
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概要
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β-Ketocarboxylic acids including β-ketoglutaric acid half-esters were cyclized by treating them with 1,1'-carbonyl-diimidazole to give 6-substituted 3-acyl-4-hydroxy-2-pyrones in good yields. 5-Aryl-3,5-dioxo-1-pentanoic acid and monomethyl malonate gave 6-aryl-4-hydroxy-2-pyrone and dimethyl β-ketoglutarate, respectively, on similar treatment. Anibin, one of the Aniba alkaloids, was synthesized from 5-(3-pyridyl)-4-hydroxy-2-pyrone. In addition, it was confirmed that reaction of magnesium β-ketocarboxylate with acylimidazolide gave the corresponding acyclic β-diketone in excellent yield.
- 公益社団法人日本薬学会の論文
- 1981-10-25
著者
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太田 俊作
Kyoto Pharmaceutical University
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岡本 正夫
Kyoto Pharmaceutical University
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太田 俊作
京都薬科大学薬学部
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辻村 篤彦
京都薬科大学
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辻村 篤彦
Kyoto College of Pharmacy
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太田 俊作
Kyoto College Of Pharmacy
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