SYNTHESIS OF 3-SUBSTITUTED ISOCOUMARINS AND RELATED NATURAL PRODUCTS

スポンサーリンク

概要

• 論文の詳細を見る

• Several N, N-diethyl-2-acylmethylbenzamides (6) were prepared from N, N-diethyl-2-toluamides (4), and the ketoamides (6) were easily cyclized to the corresponding 3-substituted isocoumarins (8) by heating in acetic acid or xylene. This simple procedure was applied to the synthesis of thunberginol A (1), thunberginol B (2), thunberginol F (14), and a key-intermediate (8j) for achlisocoumarin I (3).

• 公益社団法人日本薬学会の論文
• 1993-06-15

著者

• 太田 俊作

  Kyoto Pharmaceutical University

• 山下 正行

  Kyoto Pharmaceutical University

• 川崎 郁勇

  Kyoto Pharmaceutical University

• 山本 智史

  Kyoto Pharmaceutical University

• 川崎 郁勇

  京都薬大

• 太田 俊作

  京都薬科大学薬学部

• 鎌田 靖弘

  Kyoto Pharmaceutical University

• 稲垣 貴代

  Kyoto Pharmaceutical University

• 桝田 縁

  Kyoto Pharmaceutical University

• 太田 俊作

  Kyoto College Of Pharmacy

• 山下 正行

  京都薬科大学薬学部

関連論文

• 簡便な腸内細菌診断法の開発
• One-Step Synthesis of 1,2,3,4-Tetrahydrobenzo[g]quinazoline-5,10-dione Derivatives from Vitamin K_3
• Ring Opening of Cyclopropanemonocarboxylates and 1,1-Cyclopropanedicarboxylates Using Samarium(II) Diiodide (SmI_2)-HMPA-THF System
• Synthesis and Application of Imidazole Derivatives. Introduction of Carbogenic Substituents into the 5-Position of 1-Methyl-1H-imidazole
• K-085(30) 漢方薬による薬物相互作用 (9) : ラット小腸ミクロソームにおける CYP3A 活性に及ぼす各種漢方方剤同時添加及び単回経口投与の影響
• 81(P-77) (1-Methyl-2,5-dioxo-3-imidazolin-4-yl)amino基を有する抗腫瘍性イミダゾール系海洋天然物の全合成(ポスター発表の部)
• Introduction of Carbogenic Substituent into the 4-Position of 1-Methyl-1H-imidazole
• P-36 甘茶成分thunberginol類の合成と抗アレルギー活性 : 構造活性相関および作用様式(ポスター発表の部)
• Synthesis and Application of Imidazole Derivatives. Synthesis of 5-Methyl-7,8,9,10-tetrahydro-5H-azepino[1,2-α]benzimidazol-7-one and Related Compounds
• A Total Synthesis of Grifolin
• Synthesis and Application of Imidazole Derivatives : Preparation of Various Diketones from 1,n-Bis(1-methyl-1H-imidazol-2-yl)alkane-1,n-diones
• Synthesis and Application of Imidazole Derivatives. : Synthesis of (1-Methyl-1H-imidazol-2-yl)methanol Derivatives and Conversion into Carbonyl Compounds(Organic,Chemical)
• An Efficient Biogenetic-Type Transformation of 3-Tertiary-hydroxyalkanoic Acids to Olefinic Compounds(Organic,Chemical)
• Synthesis and Application of Imidazole Derivatives. Synthesis and Acyl Activation of 2-Acyl-1-methyl-1H-imidazoles(Organic,Chemical)
• tert-Butyl Carboxylatesの一改良合成法について
• 縮合Indole-4,7-dione関連化合物の合成研究(第3報)γ-Amino-n-butyric Acidおよびγ-Amino-β-hydroxy-n-butyric Acidを用いるPyrrole-2-acetic Acid誘導体の合成
• Use of β-Ketocarboxylic Acids for Syntheses of 6-Substituted 4-Hydroxy-2-pyrones and Acyclic β-Diketones
• A Novel and Versatile Separation Method for Aldehydes
• Studies on the Syntheses of Condensed Indole-4,7-diones. II. Synthesis of Pyrrolo [1,2-a] indole-5,8-dione Derivatives
• 縮合Indole-4,7-dione関連化合物の合成研究(第1報)2,3-Dichloronaphthoquinoneを出発原料とするBenz[f]indole-4,9-dione誘導体の合成
• Isocarbostyril関連化合物の合成研究(第5報)2-Acylamido-3-aminoisocarbostyrilの閉環反応
• 10 メラニン生合成阻害活性天然物(±)-Linderol Aの全合成(口頭発表の部)
• RING OPENING OF CYCLOPROPANECARBOXYLATES USING SAMURIUM(II) DIIODIDE (SmI_2)-HMPA-THF SYSTEM
• Synthetic Approaches to 3-Amino-1,4-naphthoquinone-2-carboxylic Acid Derivatives and Photochemical Synthesis of Novel 1,4,5,10-Tetrahydro-5,10-dioxo-2H-naphth[2,3-d][1,3]oxazine Derivatives
• Stereochemistry of Decahydroisoquinolines and Related Compounds. VIII. Syntheses of trans-4-Hydroxy-2-methyldecahydroisoquinolines
• Synthetic Studies on Lycoricidine and Related Compounds. II. Total Synthesis of (±)-Lycoricidine
• Synthetic Studies on Lycoricidine and Related Compounds. I. Synthesis of 4aH-r, 2H-cis, 2-Hydroxy-8,9-methylenedioxy-2,3,4,4a-tetrahydro-6 (5H)-phenanthridone
• Isocarbostyril関連化合物の合成研究(第4報)2,3-Diaminoisocarbostyrilのアシル化
• Isocarbostyril関連化合物の合成研究(第3報)2-Methyl-3-aminoisocarbostyrilとp-置換ベンズアルデヒドの反応
• Isocarbostyril関連化合物の合成研究(第2報)2-Methyl-3-aminoisocarbostyrilとベンズアルデヒドの反応
• Isocarbostyril 関連化合物の合成研究(第1報) : 2-Methyl-3-aminoisocarbostyril と酸クロリドの反応
• Conversion of Ketone Trimethylsilylcyanohydrins to Several Types of Compounds
• SYNTHESIS OF 3-SUBSTITUTED ISOCOUMARINS AND RELATED NATURAL PRODUCTS
• Synthesis and Application of Triazole Derivatives. Syntehsis of 3- and 5-Acyl-1,2,4-triazoles via Lithiation of 1-Alkyl-1H-1,2,4-triazoles
• メラニン生合成阻害活性天然物リンデロールAの合成研究
• 83(P-14) 5(4)-Alkenylimidazole類の新規Diels-Alder二量化反応を鍵とする生理活性海洋天然物Ageliferinsの全合成研究(ポスター発表の部)
• 木本正七郎先生を偲んで
• Photo-Oxidation of 2-Methylamino-3-(1-piperidinylmethyl)-1,4-naphthoquinone
• 水溶液Hydronaphthoquinone誘導体の合成と臨床化学における過酸化水素定量への応用
• Synthesis and Application of Imidazole Deribatives. Synthesis of Pyrrolo[1,2-a]benzimidazoles and Azepino[1,2-a]benzimidazoles
• 触媒的C-H結合官能基化によるN-無保護複素環の選択的C-アリール化
• 10,11-Dihydro-5H-dibenzo[a, d]-cycloheptene誘導体の合成研究
• コレステロール抑制物質Breynin A Aglycon((+)-Breynolide)の全合成
• 合成化学における1-Acylimidazoleの新しい利用

もっと見る 閉じる

スポンサーリンク