デカハイドロイソキノリン誘導体の立体化学(第12報) 2-Methyl-7-amino-cis-decahydroisoquinolineの合成
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概要
- 論文の詳細を見る
The two isomers (IIa and IIb) of 2-methyl-7-amino-cis-decahydroisoquinoline, which were obtained by catalytic hydrogenation of 2-methyl-7-amino-1,2,3,4-tetrahydroisoquinoline (I), were also prepared from the corresponding decahydroisoquinolinols (IIIb and IIIa) via their tosylates. Deamination of IIa or IIb with nitrous acid was found to give a product which contained a mixture of alcohols (IIIa and IIIb) and the olefinic compounds (V and VI). Some mechanistic considerations were also presented for the deamination reaction.
- 公益社団法人日本薬学会の論文
- 1976-02-25
著者
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岡本 正夫
Kyoto Pharmaceutical University
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岡本 正夫
京都薬科大学
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木本 正七郎
京都薬科大学
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尾崎 建一
京都薬科大学
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岩佐 寿子
京都薬科大学
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富田 敏夫
日本新薬株式会社
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