Characterization of Truncated Human Mannan-Binding Protein (MBP) Expressed in Escherichia coli
スポンサーリンク
概要
- 論文の詳細を見る
Mannan-binding protein (MBP) is a calcium-dependent mammalian serum lectin important in first-line host defense. MBP belongs to the collectin family, which is characterized by an NH_2-terminal cysteine-rich domain, a collagen-like domain, a neck domain, and a carbohydrate recognition domain (CRD). We have expressed a recombinant human MBP, consisting of the short collagen region (two repeats of Gly-Xaa-Yaa amino acid sequences), the neck domain, and the CRD, in Escherichia coli. The truncated MBP was capable of forming trimers by association of the neck domain and could bind sugar with a specificity similar to that of the native form. Results of hemagglutination inhibition (HI) assay of influenza A virus showed that the truncated MBP inhibited hemagglutination less strongly, although the native MBP induced the HI phenomenon. These results suggest that an oligomeric structure is an advantage for MBP to have full biological activity against influenza A virus.
- 社団法人日本農芸化学会の論文
- 1998-07-23
著者
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WAKAMIYA NOBUTAKA
Department of Microbiology, Asahikawa Medical College
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OHTANI KATSUKI
Department of Pediatric Cardiology, Hirosaki University School of Medicine
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Sakamoto Takashi
Department of Cardiology, Kyoto prefectural Yosanoumi Hospital
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Suzuki Yasuhiko
Department of Microbiology and Immunochemistry, Asahikawa Medical College
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Ohtani Katsuki
Department Of Microbiology And Immunochemistry Asahikawa Medical College
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Suzuki Yoshihito
Dep. Of Applied Biological Chemistry Univ. Of Tokyo
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EDA Souji
Department of Biological Science Research, Research & Development Center, Fuso Pharmaceutical Indust
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Suzuki Y
Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control
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Suzuki Yoshihito
Department Of Applied Biological Chemistry The University Of Tokyo
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Suzuki Yoshihito
The Institute Of Enology And Viticulture Yamanashi University
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Wakamiya Nobutaka
Department Of Microbiology And Immunochemistry Asahikawa Medical College
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Suzuki Y
Research Institute For Bioresources Okayama University
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Eda Souji
Department Of Biological Science Research Research & Development Center Fuso Pharmaceutical Indu
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Kase T
Divisions Of Virology Osaka Prefectural Institute Of Public Health
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Kawai T
Department Of Food Microbiology Osaka Prefectural Institute Of Public Health
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Katoh Tsuyoshi
Department Of First Biochemistry Asahikawa Medical College
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KAWAI Takao
Food Microbiology
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KASE Tetsuo
Virology, Osaka Prefectural Institute of Public Health
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Sakamoto Takashi
Department Of Cardiology Kyoto First Red Cross Hospital
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Saito Tetsuya
Research & Development Center Fuso Pharmaceutical Industries
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Sakamoto Takashi
Department Of Aquatic Biosciences Tokyo University Of Fisheries
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Suzuki Yasuhiko
Department Of Global Epidemiology Research Center For Zoonosis Control Hokkaido University
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Suzuki Yasuhiko
Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control
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SUZUKI Yasuhiko
Department of Chemistry, Shizuoka University
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