Anti-Influenza A Virus Activities of Mannan-Binding Lectins and Bovine Conglutinin
スポンサーリンク
概要
- 論文の詳細を見る
Mannan-binding lectin (MBL) and bovine conglutinin (BKg) belong to the collectin family, which is involved in first-line host defense against various infectious agents. We have previously reported that human MBL inhibited type A influenza viral hemagglutination, infection and spreading to adjacent cells without complement activation. In this study, we investigated the direct antiviral activities of bovine MBL, rabbit MBL and BKg. All collectins used in this study inhibited viral infectivity and hemagglutination at concentrations of 0.02-0.3 μg/ml. They also demonstrated inhibitory activity against viral spreading. Like human MBL, bovine MBL and BKg showed antiviral activities at their physiological concentrations. These results suggest that mammalian MBLs and BKg may inhibit the spread of influenza A virus through the bloodstream.
- 公益社団法人 日本獣医学会の論文
著者
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Ohtani Katsuki
Department Of Microbiology And Immunochemistry Asahikawa Medical College
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Wakamiya Nobutaka
Department Of Microbiology And Immunochemistry Asahikawa Medical College
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Eda Souji
Department Of Biological Science Research Research & Development Center Fuso Pharmaceutical Indu
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Sakamoto Takashi
Department Of Aquatic Biosciences Tokyo University Of Fisheries
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Suzuki Yasuhiko
Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control
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Kawai Takao
Department of Biochemistry, Asahikawa Medical University
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WAKAMIYA Nobutaka
Department of Microbiology and Immunochemistry, Asahikawa Medical College
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KASE Tetsuo
Department of Infectious Diseases, Osaka Prefectural Institute of Public Health
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SUZUKI Yasuhiko
Department of Chemistry, Shizuoka University
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KAWAI Takao
Department of Infectious Diseases, Osaka Prefectural Institute of Public Health
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