EFFECTIVENESS OF CAPREOMYCIN AGAINST EXPERIMENTAL TUBERCULOSIS OF MICE AND GUINEA PIGS

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For the purpose to examine the antituberculous activity of capreomycin, two types of animal experiment were conducted. In the first experiment, the effectiveness of capreo mycin was evaluated by comparing the survival days of treated mice with those of control mice under the fatal course of infection. Seventy-five male albino mice of commercial dd strain were divided into 5 groups of equal 15. All the animals were intravenously infected with 0.5 mg of a bovine strain of tubercle bacilli (Ravenel) grown on Sauton synthetic liquid medium. Intraperitoneal drug administration to 4 groups was started 3 days after infection with 1 mg, 2 mg, 4 mg daily dose of capreomycin, or with 2 mg of kanamycin, respectively. Drug adminis tration was conducted every day during the period of 19 days except 2 Sundays. Then, the mice were kept nourished until 68 days after infection, and the survival day of each animal was checked. The result is presented in Fig. 1. As shown in this figure, all the untreated mice died during the period from 20 to 27 days after infection, but the survival days of the treated mice were prolonged more or less. Particularly, all the animals administered with 4 mg of capreomycin or 2 mg of kanamycin survived the entire experimental period.<BR>In the second experiment, 65 male white guinea pigs were subcutaneously injected in the right side of the under abdomen with 0.01 mg of Ravenel strain of the same culture as that used in the mouse experiment. Then, they were left nourished expecting the establishment of advanced tuberculosis. Four weeks after infection, 5 of them were sacrificed to confirm the grade of tuberculous involvement by macroscopic observation and bacillary culture of the lungs, liver and spleen. At the same time, the animals were divided into 4 groups of 10 animals and 4 groups of 5. One group of 10 animals was further left untreated, and 3 other groups of 10 animals were treated with 10 mg, 20 mg, or 40 mg daily dose of capreomycin respectively. Against 4 groups of 5 animals, 10 mg of streptomycin, 10 mg of kanamycin, 2 mg of INH or 10 mg of TB1 was administered. Subsutaneous route of administration was employed for capreomycin, streptomycin, and kanamycin, but INH and TB1 were given orally. Daily administration was continued for 5 weeks. Three days after the termination of treatment, all the animals were sacrificed, and the comparative observation of tuberculous involvement and the bacillary culture of the spleen and the lungs were conducted. The figures as presented in the text indicate that capreomycin is effective against established tuberculous infection in guinea pigs, particularly in almost the same grade as streptomycin and kanamycin, if the dose is twice as much as the latter drugs or more.
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EFFECTIVENESS OF CAPREOMYCIN AGAINST EXPERIMENTAL TUBERCULOSIS OF MICE AND GUINEA PIGS

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