短期強化化学療法の検討を目的とするマウス結核症の治療実験 (I)

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With a basic idea that elimination of persistent bacilli to the minimum level, if not eradication, is the best way to reduce the possibilities of relapse in later years, an attempt was made to work out highly efficient short-course regimens through experimental model in mouse tuber culosis.<BR>The experiment was designed as shown in Fig. 1 and the results are demonstrated in Figs.2 and 3. The daily administration of three drugs, e. g. INH+RFP+SM or INH+RFP+EB, in an appropriate dose was found to be capable of eliminating infecting bacilli down to the undetect able level in a month or so. Even after cessation of the treatment, this “sterilized” condition was kept for some weeks, and then the bacilli began to make irregular appearance in the lung within a limited level of viable counts. In the spleen the reappearance of the bacilli was more consistent than in the lung. Nevertheless, the therapeutic effect as obtained here was so remarkable as never been experienced by us before the time when rifampicin became available.<BR>Futher experiments are now under way to improve the regimen, particularly by adjusting the period of treatment.
日本結核病学会の論文