感染菌の増殖度と結核化学療法効果-2-種々な感染条件における観察

概要

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1) Isoniazid-treatment was poor in its effectiveness on tubercle bacilli of the secondary infection whose multiplication was inhibited under the pressure of acquired immunity induced by the primary infection. 2) Mice were infected intravenously with tubercle bacilli preexposed in vitro to a low concentration of streptomycin (5 μg/ml). Isoniazid-treatment with 0.5 mg daily dose was less effective on these infecting bacilli than on the unexposed control bacilli. 3) The multiplication of infecting tubercle bacilli was accelerated by cortisone-administration. Isoniazid-treatment was highly effective on those bacilli as revealed by remarkable reduction of viable counts in the spleen. 4) From these observations it was concluded that isoniazid-treatment was more effective when infecting bacilli were more active in multiplication.
一般社団法人日本結核病学会の論文