TUBERCULOUS INFECTION AS VIEWED FROM THE TURNOVER OF HOST CELL LIPIDS

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Microbial surfaces are one of the important determinants for their pathogenicity in relation with the interaction with the surface of host cells. In intracellular infections such as tuberculosis, the inter action between the membrane structure of phagocytes and the surface of ingested bacteria will be causally related with the development of infection. We had a particular interest in a possibility that hydrophobic mycobacterial surface due to the high content of lipids has a strong affinity to the lipid bilayer of the phagocytic cell membrane to induce the change of lipid metabolism there.<BR>To examine this possibility, a biochemical and bacteriological study has been conducted with the cell and tissue materials from normal and infected mice and guinea pigs. The results indicated that the active turnover of fatty acids in the membrane of host cells is resulted from the interaction with the bacilli, most probably starting from the activation of the membrane-bound phospholipase A<SUB>2</SUB>. Cholesterol and cholesterol esterase in the membrane as well as mycobacterial lipids and enzymes were found to be participating in the above turnover. Released fatty acids in free form, at least in part, were suggested to play a dual activity to promote or inhibit mycobacterial growth depending upon their concentration in situ and the environmental condition, particularly at the site of close contact between the cell membrane and the bacillus.
一般社団法人日本結核病学会の論文

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近藤瑩子
国立予防衛生研究所細菌1部・結核部

TUBERCULOUS INFECTION AS VIEWED FROM THE TURNOVER OF HOST CELL LIPIDS

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