結核化学療法終了後における再発防止を目的とした免疫増強剤使用の検討

概要

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Experimentally infected tuberculous mice were treated by intensive chemotherapy with three drug combinations (SM×INH×RFP, EB×INH×RFP or SM×INH×PZA) for 5 months so that viable counts from the spleen and lung were decreased down below the undetectable level.<BR>After termination of chemotherapy, the mice of each group were divided into two groups, which subsequently received or did not receive intravenous administration of, β-1, 3 glucan, 0.5mg once a week, for 4 weeks and again 4 weeks after one month interval.<BR>During this period and the succeeding 5 months, the mice were subjected to occasional sacrifice at random for cultivation of the two organs to detect the reincrease of latent tubercle bacilli therein. The results indicated that the regimens with SM×INEH×RFP or with EB×INH×RFP was highly efficient in eradicating infecting tubercle bacilli in mice, if not perfectly, and the use of β-1, 3 glucan as an immunoadjuvant was effective in preventing the reincrease of latent bacilli.
日本結核病学会の論文