結核感染における宿主脂質 : III.長鎖脂肪酸と結核菌

概要

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The molecule of long-chain fatty acids consists of two moieties, hydrophobic hydrocarbon chain and hydrophilic carboxyl group. Because of this chemical structure, long-chain fatty acids are surface-active, membrane-active, and cytotoxic. However, such toxicity is usually masked in vivo by being coupled with proteins or being esterified to triglycerides, phospholipids, and cholesteryl esters. In triglycerides, fatty acids serve as an energy reservoir. In phospholipids, the acyl chains of fatty acids give the membrane the properties of hydrophobicity and fluidity which interfer in many ways with the physiology of the cell.<BR>The 3rd part of this review is concerned with the dual effects of long-chain fatty acids on tubercle bacilli, growth-supporting or growth-inhibitory depending upon the concentration and other physicochemical factors in the environment. Particular interest was directed in the in vivo condition where free long-chain fatty acids may have a chance to act directly on the bacilli without being interfered by neutralizing activity of host proteins.
日本結核病学会の論文