EFFECT OF 4, 4'-DIISOAMYLOXYTHIOCARBANILIDE (ISOXYL®) IN THE EXPERIMENTAL GUINEA PIG TUBERCULOSIS

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Effect of Isoxyl (or Disoxyl®) on the guinea pig tuberculosis was reinvestigated by 2 experiments employing per oral administration of the drug homogeneously suspended in camellia oil. White, male guinea pigs weighing 300-400g were infected subcutaneously each with 0.01mg of M. bovis (Ravenel strain) prepared from 9 day old pellicle on Sauton liquid medium. Then, the animals were divided into 11 groups as shown in Table 1. Isoxyl powder in the purity of 99.9% (Meiji Seika, Co. Ltd.) was suspended in camellia oil and 0.5ml of it was administered orally for 5 weeks, 6 times weekly employing a silver tube. No difference was observed in the body weight curves among the groups in Exp. I as shown in Fig. 1. Contrary to this, marked decrease was observed in the non-treated control in Exp. II from 9th to 11th week after infection. In Exp. I, induration formed at the infection site one week after infection disappeared completely in the treated groups (3-6), whereas in the control group it developed into ulcer. In Exp. II, ulcer formed on the infection site healed completely in the groups of 8, 9 and 11 as early as 3 weeks after the initiation of treatment, and 80% in the group 10 (50mg Isoxyl) after 5 weeks drug administraion. Autopsy findings and the bacterial number recovered from viscera are shown in Fig. 2, 3 and 4. In the experiment in which drug administration was started shortly after infection, 100-125mg/kg of Isoxyl was very effective. Even in the case of advanced tuberculosis, 200-400mg Isoxyl per kg was also effective without accompanying any unfavourable side effect such as body weight decrease etc. These results suggest that Isoxyl, which is insoluble in water, can be administered in the form of oil suspension with better effect in the treatment of experimental tuberculosis.
一般社団法人日本結核病学会の論文

EFFECT OF 4, 4'-DIISOAMYLOXYTHIOCARBANILIDE (ISOXYL<SUP>®</SUP>) IN THE EXPERIMENTAL GUINEA PIG TUBERCULOSIS

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