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We employed immunofluorescent staining on formalin-fixed paraffin sections improved by trypsin digestion to exsamine the mucosal expression of secretory component (SC), IgA and CEA in normal and pathologic lesions of the stomach and the colon.This method may be simple as compared with PAP method, and a useful adjuvant to histopathologic study, in which a retrospective immunohistochemical examination may be desireble. By trypsin digestion formalin-fixed paraffin section shows a equivalent staining to ethanol fixed one.Normal colonic mucosa shows strong stainings of SC, IgA, and CEA as compared with normal gastric mucosa. Gastric and colonic carcinomas show decreased stainings of SC and IgA and increased stainings of CEA. In adenomatous polyp of the colon, stainings of SC, IgA and CEA are closely correlated with the grades of cellular and structural atypia. These comparative immunohistochemical study will be able to become one of the useful methods to exsamine either cancer-adenoma sequence in the colon or causal relation between gastric carcinoma and intestinal metaplasia.
財団法人日本消化器病学会の論文