線維素の動態病理学, 特に局所アナフィラキシーに於けるその意義に関する組織学的並びに病態生理学的研究 : アレルギー性炎症に於ける線維素溶解酵素の意義並びに類線維素変性の本態について

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Morphological and patho-physiological dynamic observation on the fibrin in the Arthus phenomenon were carried out. Histochemically, the fibrinoid degeneration of connective tissue fibres may be classified to three phases. Namely, I. dehydrated and atrophied phase, II. fibrinoid swelling phase and III. fibrinoid necrosis. Polysaccharide positive reactions were observed only at Ist phase. But fibrin positive reactions were far dominant at all phases. Loosening of collagen fiber to Ag-fibres and its dehydrating state were resulted by exsudation with intense absorption ability of various substances. The swelling state of collagen fiber was decreased the absorption ability. And, in maximum degeneration, fibres were brocken completely to pieces and inhibited with exudating plasma proteins particularly with fibrin. By administration of plasma to the Arthus phenomenon, the reaction was on the contrary repressed. Histological findings showed decreased thrombi and none of fibrin and fibrinoid in the lesioned tissue. Therefore, the presence of fibrin may be necessary to the formation of the fibrinoid and the establishment of the local anaphylaxis. Mere activation of plasmin in blood was not caused the generalized anaphylactic shock nor the local anaphylaxis in rabbits. Three or five days after the Arthus phenomenon, fibrinolytic activities in blood and lesioned tissues were observed to be activated. Thrombi and fibrin fibres in the bottom layers of the corium were dissolved, which are characterized with dense vascular network, and it was effective to the tissue repair process, while the middle layer of the corium was coarse vasculated, thrombi were less dissolved and the upper parts were observed to form the demarcating necrosis.
日本アレルギー学会の論文
1960-04-01

線維素の動態病理学, 特に局所アナフィラキシーに於けるその意義に関する組織学的並びに病態生理学的研究 : アレルギー性炎症に於ける線維素溶解酵素の意義並びに類線維素変性の本態について

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