β-アミノプロピオニトリル及びD-ペニシラミン投与によるコイの骨の機械的強度並びに骨及び皮のコラーゲン溶解性の変化

概要

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β-Aminopropionitrile (β-APN) and D-penicillamine, when administered orally to carp, caused a marked decrease in the mechanical strength of the vertebral column and an increase in the amount of soluble collagen in the bone and skin. Intraperitoneal administration of these drugs to carp also caused a reduction in the mechanical strength of the bone. When β-APN and D-penicillamine were added to acid-soluble collagen derived from normal carp skin, D-penicillamine, in contrast to β-APN, prevented the formation of stable collagen fibrils in vitro. These results indicate that the skeletal deformity induced in carp by β-APN and D-penicillamine is due to the reduced mechanical strength of the bone resulting from a collagen maturation defect.
公益社団法人日本水産学会の論文