The study of factors affecting the elevation of fasting serum total bile acid concentrations in liver cirrhosis. A comparative study with idiopathic portal hypertension.:A comparative study with idiopathic portal hypertension

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In idiopathic portal hypertension, in which liver parenchyman cell damage is minimal, the intrahepatic shunt index was not correlated with fasting serum total bile acid concentrations (F-TBA) but large extrahepatic shunts clearly raised F-TBA.<BR>In liver cirrhosis, the effect of large extrahepatic shunts on F-TBA was not clearly demonstrated and the higher activity of parenchymal cell damage was shown to have an unequivocal effect on elevating F-TBA, and in cases without large extrahepatic shunts and higher activity, the intrahepatic shunt index was positively correlated with F-TBA (r=0.904, p<0.001) suggesting that intrahepatic shunt is a predominant factor to elevate F-TBA in such cases.
社団法人日本肝臓学会の論文