Integration of duck hepatitis B virus DNA in duck hepatocellular carcinoma. State of duck hepatitis B virus DNA in liver tissue.

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The state of duck hepatitis B virus (DHBV) DNA in liver and serum was studied in 23 ducks from Chi-tung county in China by the Southern blot and spot hybridization techniques. In 16 of 23 (70%), DHBV DNA was detected in serum and/or in liver tissue. One DHBV DNA seropositive duck had a large hepatocellular carcinoma. Southen blot analysis clearly demonstrated integrated DHBV DNA in neoplastic tissue, and abundant episomal DHBV DNA in non-neoplastic tissue of the liver. In one duck with a small adenoma, no viral DNA was detected in tumor or non-neoplastic tissue. These infected ducks showed a variety of pathological changes including advanced chronic disease in the liver. In contrast, none of the virus free ducks had advanced hepatic changes.<BR>These results suggest that DHBV behave like human and woodchuck hepatitis viruses as relates to chronic liver disease and hepatocellular carcinoma.
社団法人日本肝臓学会の論文