原発性胆汁性肝硬変症の各病期における肝容積と肝細胞DNA合成能についての検討 : CT scanおよびBrdU labeling indexによる検討

概要

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The relationship between the liver volume and DNA synthetic potency of hepatocytes from biopsied specimens was investigated in various stages of PBC using computed tomography and in vitro BrdU-anti BrdU technique. The mean (±SE) liver volume in the early stage of PBC (1225±40cm3) was about 1.5 times that in control subjects (835±42cm3, p<0.001). The mean BrdU (±SE) Labeling Index (LI) for 10 patients with early histologic stage of PBC (3.4± 0.4%) was 17 times that for 6 control subjects (0.2±0.1, p<0.001), and was significantly higher than that for 19 patients with chronic aggressive hepatitis (0.9±0.2, p<0.01), 14 control cirrhotic patients of viral origin (1.0±0.3, p<0.01). These results would demonstrate that liver volume has already become large in the early stage of PBC because of markedly increased DNA synthetic potency in hepatocytes.
社団法人日本肝臓学会の論文