肝細胞癌およびその発生母地肝硬変の Bromodeoxy uridine の取り込みより見たDNA合成能について

概要

論文の詳細を見る
The in vitro uptake of bromodeoxyuridine (BrdU) was studied in 49 patients with various liver diseases (including 13 patiellts with HCC, 11 with LC, 20 with CAH and 5 with alcoholic liver fibrosis), using liver biopsy specimens. The labeling index of BrdU was highest in cancerous portion of HCC (5.7±0.9%), and was second highest in non-cancerous cirrhotic portion of HCC patients (3.4±0.4), followed by LC without HCC (2.3±0.7%) and alcoholic liver fibrosis (2.4±0.7%). Unexpectedly, the L.I. was lowest in CAH (10±0.1%). The L.I. in cancerous portion of HCC patients was significantly higher than those in the other groups. The L.I. in non-cancerous cirrhotic portion of HCC patients was not significantly higher in Student's t test, but was significantly higher in X2 test, as compared with that in LC without HCC.
社団法人日本肝臓学会の論文