Antiallergic Effects of ZCR-2060: Effect on Allergic Cutaneous Reactions and Rhinitis Models in Mice and Rats.
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概要
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The antiallergic action of 2-[2-[4-(diphenylmethyl)-1-piperadinyl]ethoxy] benzoic acid maleate (ZCR-2060) was investigated on allergic cutaneous reactions and nasal vascular permeability in mice and rats. ZCR-2060 markedly inhibited immediate allergic cutaneous reactions, including passive cutaneous anaphylaxis (PCA) in rats and mice; histamine-, compound 48/80- and calcium ionophore A 23187-induced cutaneous reactions in rats; and biphasic skin reactions mediated by monoclonal IgE antibody and epicutaneous challenge with antigen in mice, but did not affect 5-hydroxytryptamine-induced cutaneous reaction in rats. The antigen-induced nasal vascular permeability increase in actively and passively sensitized rats and histamine-induced nasal vascular permeability increase in rats (allergic rhinitis model) were clearly inhibited in a dose-dependent fashion by ZCR-2060. Moreover, ZCR-2060 significantly inhibited antigen-induced anaphylactic histamine release from rat peritoneal mast cells and carrageenin-induced paw edema in rats. These results suggest that ZCR-2060 has antiallergic effects on allergic cutaneous reactions and experimental rhinitis, probably due to histamine H<SUB>1</SUB>-receptor blockage and the inhibition of histamine release.
- 公益社団法人 日本薬理学会の論文
著者
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Omata Takeshi
Department Of Applied Research Central Laboratories Zeria Pharmaceutical Co. Ltd.
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Segawa Yoshihide
Department Of Pharmacology Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Matsuda Kazuo
Department Of Agricultural Biochemistry Faculty Of Agriculture Tohoku University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Yoshida Kenji
Department of Biochemistry, Kinki University School of Medicine
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Abe Tooru
Department of Pharmacology, Gifu Pharmaceutical University
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Matsuda Kazuo
Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
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