Two apparently distinct muscarinic cholinoceptor mechanisms in guinea-pig taenia caecum.
スポンサーリンク
概要
- 論文の詳細を見る
Thirty-min treatment of guinea-pig taenia caecum with 300 nM propylbenzilylcholine mustard (PrBCM) shifted the concentration-response curve for carbachol to the right with a reduction of the maximum contraction, but 90-min treatment did not result in further inhibition. Under these conditions, pilocarpine hardly contracted the preparations, and it competitively antagonized carbachol. Muscarinic agonists might interact with two types of receptor mechanisms and carbachol elicited a stimulus from both types, whereas pilocarpine did so predominantly from the PrBCM-sensitive one.
- 公益社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Hisayama Tetsuhiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Kumagai Naomi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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