Provisional chromosome assignment of the rat major histocompatibility complex
スポンサーリンク
概要
- 論文の詳細を見る
Somatic cell hybrids between an AKR mouse thymic lymphoma cell line and normal F344 rat spleen cells were isolated in order to assign the rat major histocompatibility complex (MHC) (RT1) to a specific chromosome. Six primary hybrid clones and 3 of their derivatives were examined for expression of the RT1 antigens on the cell surface by the complement-dependent cytotoxicity test and simultaneously for their karyotypes by the Hoechst 33258/quinacrine mustard double staining method. All of these hybrid clones consisted of 2 sets of mouse and 1 set of rat parental cells, with a preferential loss of rat chromosomes. A high degree of concordance was shown between the expression of the RT1 antigen and the presence or absence of rat chromosome 14 in the original 6 hybrid clones. This was confirmed in 1 spontaneous and 2 immunoselected RT1-negative segregants from RT1-positive clones. These results led us to propose that the rat MHC is located on chromosome 14.
著者
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SASAKI MOTOMICHI
Chromosome Research Unit, Hokkaido University
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SATOH Hitoshi
Chromosome Research Unit, Faculty of Science, Hokkaido University
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Yoshida Michihiro
Chromosome Res. Unit Fac Sci. Hokkaido Univ.
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Kobayashi Hiroshi
Laboratory Of Food Hygienic Chemistry Division Of Food Biotechnology Department Of Bioscience And Bi
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SATOH Hitoshi
Chromosome Research Unit, Faculty of Science, Hokkaido University
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及川 恒之
Laboratory of Genetics, Cancer Institute, Hokkaido University School of Medicine
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YAMASHINA Kenji
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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KOBAYASHI Hiroshi
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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OIKAWA Tsuneyuki
Laboratory of Genetics, Cancer Institute, Hokkaido University School of Medicine
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SASAKI MOTOMICHI
Chromosome Research Unit, Faculty of Science, Hokkaido University
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