Does human immunodeficiency virus type-1 integrate in chromosomes randomly?
スポンサーリンク
概要
- 論文の詳細を見る
During the life cycle of retroviruses, including human immunodeficiency virus type 1 (HIV-1), integration of a double stranded DNA copy of viral genome into the host cellular DNA is essentially required. The integration sites of HIV-1 genome within the persistently infected human leukemia cell lines were investigated by fluorescence in situ hybridization (FISH) process using a NarI/XhoI fragment of pNL432 clone of HIV-1 as a probe. In L-2, 15L, 26L and 5H cell lines, each HIV-1 integration site was assigned to 8p11.2, Xp11.3-p11.4, 20q13.1-q13.3, and 21q22.1-q22.3, respectively. In the MOLT-4/LAV-1 cell line HIV-1 was integrated on two chromosomes 1q21-q23 and 8q11-q12. These integration sites appeared to be correspondent to loci of oncogenes and genes related to DNA synthesis and cell cycle.
- 財団法人染色体学会の論文
著者
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Ikuta K
Hokkaido Univ. Sapporo Jpn
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YOSHIDA Michihiro
Chromosome Research Unit, Faculty of Science, Hokkaido University
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IKUTA Kazuyoshi
Section of Serology, Institute of Immunological Science,Hokkaido University
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TAKAHASHI Hirokazu
Section of Serology, Institute of Immunological Science, Hokkaido University
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Takahashi Hirokazu
Section Of Serology Institute Of Immunological Science Hokkaido University
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Bahmani Mirza.
Section Of Serology Institute Of Immunological Science
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Ikuta Kazuyoshi
Section Of Serology Institute Of Immunological Science
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SAADAT Mostafa
Department of Biology, College of Sciences, Shiraz University
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BAHMANI Mirza
Section of Serology, Institute of Immunological Science
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Saadat Mostafa
Department Of Biology College Of Sciences Shiraz University
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Yoshida Michihiro.c.
Chromosome Research Unit Faculty Of Science Laboratory Of Cytogenetics Division Of Biological Scienc
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Yoshida Michihiro
Chromosome Res. Unit Fac. Sci.:lab. Cytogenet. Grad. Sch. Environ. Earth Sci. Hokkaido Univ.
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Yoshida Michihiro
Chromosome Res. Unit Fac. Sci. Hokkaido Univ.
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Yoshida Michihiro
Chromosome Res. Unit Fac Sci. Hokkaido Univ.
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Yoshida Michihiro
Laboratory Of Cytogenetics Graduate School Of Environmental Earth Science Hokkaido University:chromo
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Yoshida C.
Chromosome Research Unit Faculty Of Science Hokkaido University And Division Of Bioscience Graduate
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Yoshida -c.
Chromosome Research Unit Faculty Of Science And Division Of Biological Science Graduate School Of En
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Takahashi Hirokazu
Section Of Serology Institute Of Immunological Science
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Yoshida C.
Chromosome Research Unit Faculty Of Science Graduate School Of Environmental Earth Science Hokkaido
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Yoshida Michihiro
Chromosome Research Unit Hokkaido University
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Yoshida Michihiro
Chromosome Reserch Unit Hokkaido University
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C. Yoshida
Chromosome Research Unit Faculty Of Science Hokkaido University
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Yoshida Michihiro
Chromosome Research Unit Faculty Of Science Laboratory Of Cytogenetics Division Of Biological Scienc
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