Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats.
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概要
- 論文の詳細を見る
LEC rats develop disorder of copper metabolism and hepatitis similar to those of human Wilson's disease. We recently demonstrated that the gene responsible for hepatitis (hts) of LEC rats is homologous to Wilson's disease gene (WD). The present study showed a deletion of at least 90 base pair of WD cDNA in LEC rats, which corresponds to nucleotides 3981 to 4071 in human WD cDNA sequence. This deletion was linked with hepatic copper accumulation and hepatitis, and considered to be a primary mutation for hepatic disorder in the LEC rat. The WD gene was assigned to rat chromosome 16 at band q12.2-q12.4 by fluorescence in situ hybridization (FISH).
- 日本遺伝学会の論文
著者
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Ono Takao
Chromosome Research Unit Faculty Of Science Hokkaido University:department Of Genetics Institute For
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Kondoh Yasumitsu
AISIN COSMOS R & D CO., LTD.
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Yoshida Michihiro
Chromosome Res. Unit Fac Sci. Hokkaido Univ.
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FUKUMOTO Risaku
Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University
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