Expression of Borna Disease Virus Messages in Clinical Samples from Patients with Brain Malignant Tumors

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概要

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• Borna disease virus (BDV), a nonsegmented, negative-sense, single-stranded RNA virus with an envelope, was initially isolated from horses with poliomyeloencephalitis. BDV is also believed to be linked with psychiatric disorders in humans based on higher prevalences of serum antibodies against BDV and viral RNA footprints in peripheral blood mononuclear cells of psychiatric patients, compared with those of controls. Here, we show that BDV RNA was identified in total RNA extracted directly from clinical samples of brain tumors. We found that two and three samples were positive using primers for the p24 and p40 regions, respectively, among grade 4 malignant tumors (glioblastomas) from 16 patients. There were no positive samples among lower grades of tumors (pilocytic or anaplastic astrocytomas) from 21 patients at either region. Of particular note is the detection of either a p40 or a p24 RNA in each of the tumor samples. Thus, we detected BDV RNA for the first time in the brains of immunosuppressed patients.

• 日本学士院の論文

著者

• Sakuma Shiro

  Department Of Neurosurgery Hokkaido University School Of Medicine

• Tada Mitsuhiro

  北海道大学 脳神経外科

• Tada Mitsuhiro

  Department Of Neurosurgery University Of Hokkaido School Of Medicine

• TAKAHASHI Hirokazu

  Hokkaido University

• NAKAYA Takaaki

  Hokkaido University

• Abe Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Nakaya Takaaki

  Section Of Serology Institute Of Immunological Science Hokkaido University

• SAWAMURA Yutaka

  Department of Neurosurgery, Hokkaido University Hospital

• IKUTA Kazuyoshi

  Section of Serology, Institute of Immunological Science,Hokkaido University

• TAKAHASHI Hirokazu

  Section of Serology, Institute of Immunological Science, Hokkaido University

• Takahashi Hirokazu

  Section Of Serology Institute Of Immunological Science Hokkaido University

• Ikuta Kazuyoshi

  Section Of Serology Institute Of Immunological Science

• Nakaya T

  Hokkaido Univ. Hokkaido Jpn

• Tada Mitsuhiro

  Department Of Chemistry Faculty Of Science Kochi University

• Sawamura Yutaka

  Department Of Bioresource Science Faculty Of Agriculture Kagawa University

• Abe Hiroshi

  Department Of Anatomy Akita University School Of Medicine

• FUJIWARA Suguru

  Section of Serology, Institute of Immunological Science, Hokkaido University

• Takahashi Hirokazu

  Section Of Serology Institute Of Immunological Science

• Abe Hiroshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

• SAWAMURA Yutaka

  Department of Neurosurgery, Hokkaido University School of Medicine

• SAKUMA Shiro

  Department of Neurosurgery, Hokkaido University School of Medicine

• Nakaya Takaaki

  Section of Serology, Institute of Immunological Science, Hokkaido University

• IKUTA Kazuyoshi

  Section of Serology, Institute of Immunological Science, Hokkaido University

• ABE Hiroshi

  Department of Neurosurgery, Hokkaido University School of Medicine

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