Antiproliferative Effect of Tumor Necrosis Factor-α on Human Glioblastoma Cells Linked with Cell Cycle Arrest in G_1 Phase
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概要
- 論文の詳細を見る
The effects of tumor necrosis factor-α (TNF) on proliferation and cell cycle alterations in human malignant glioma cell lines, SF-188 and LN-382, were investigated by flow cytometry with the bromodeoxyuridine-propidium iodide dual staining technique. Low concentrations of TNF (1-100U/ml) suppressed the growth of SF-188 assessed by cell count, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, and thymidine incorporation assay, but not that of LN-382. After TNF treatment, the percentage of SF-188 cells in the G_0/G_1 phase increased, while the percentage of cells in the S phase decreased. LN-382 cells did not show any marked change in cell kinetics. TNF arrests certain human glioma cells in the G_0/G_1 phase resulting in reduction of deoxyribonucleic acid synthesis in the subsequent S phase, suppressing the proliferation pathway.
- 日本脳神経外科学会の論文
- 1994-05-15
著者
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Sakuma Shiro
Department Of Neurosurgery Hokkaido University School Of Medicine
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Sakuma Shirou
北海道大学 脳神経外科
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Sakuma Shirou
Department Of Experiment Radiology Oncology The University Of Texas M. D. Anderson Cancer Center
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Tada Mitsuhiro
北海道大学 脳神経外科
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Tada Mitsuhiro
Department Of Neurosurgery University Of Hokkaido School Of Medicine
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Abe Hiroshi
Department Of Cardiology National Cardiovascular Center
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Cheng Kang
Department Of Neurosurgery Hokkaido University School Of Medicine
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Abe Hiroshi
Department Of Neurosurgery Hokkaido University Graduate School Of Medicine
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SAWAMURA Yutaka
Department of Neurosurgery, Hokkaido University Hospital
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AIDA Toshimitsu
Department of Neurosurgery, Hokkaido University School of Medicine
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SUDO Masako
Department of Neurosurgery, Hokkaido University School of Medicine
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Abe Hiroshi
Department Of Neurosurgery University Of Hokkaido School Of Medicine
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Sudo Masako
Department Of Neurosurgery Hokkaido University School Of Medicine
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Tada Mitsuhiro
Department Of Chemistry Faculty Of Science Kochi University
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Sawamura Yutaka
Department Of Neurosurgery University Of Hokkaido School Of Medicine
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Sawamura Yutaka
Department Of Bioresource Science Faculty Of Agriculture Kagawa University
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Abe Hiroshi
Department Of Anatomy Akita University School Of Medicine
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Suwamura Yutaka
Department Of Neurosurgery Hokkaido University School Of Medicine
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Aida Toshimitsu
Department Of Neurosurgery Hokkaido University School Of Medicine
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Abe Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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