Antiproliferative Effect of Trapidil on PDGF-associated Growth of Human Glioma Cell Lines in Vitro

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概要

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• The effects of trapidil on platelet-derived growth factor (PDGF)-associated growth of glioblastoma cells were studied. The assessment using PDGF-dependent rat lung endothelium cells revealed secretion of a PDGF-like factor from SF-126 cell line but not from SF-188. Human recombinant PDGF stimulated proliferation of both these glioblastoma cell lines. The anti-PDGF monoclonal antibody inhibited the growth of SF-126 more than SF-188. The results suggest the presence of an autocrine growth mechanism in SF-126 cells mediated by PDGF. The growth of both SF-126 and SF-188 cells was suppressed by trapidil, a specific PDGF antagonist, at 10 and 50 μg/ml, respectively. The proliferative response to exogenous PDGF and the antagonistic effect of trapidil were greater in the SF-126 cell line. In addition, trapidil markedly reduced production of prostaglandin E_2 in both glioblastoma cell lines. This anti-proliferative effect on malignant glioma cells suggests that trapidil might be a new therapeutic agent for malignant gliomas.

• 日本脳神経外科学会の論文
• 1991-06-15

著者

• KOBAYASHI Hiroshi

  Laboratory of Food Hygienic Chemistry, Division of Food Biotechnology, Department of Bioscience and

• Tada Mitsuhiro

  北海道大学 脳神経外科

• Tada Mitsuhiro

  Department Of Neurosurgery University Of Hokkaido School Of Medicine

• Abe Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Abe Hiroshi

  Department Of Neurosurgery Hokkaido University Graduate School Of Medicine

• SAWAMURA Yutaka

  Department of Neurosurgery, Hokkaido University Hospital

• HOSOKAWA Masuo

  Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine

• AIDA Toshimitsu

  Department of Neurosurgery, Hokkaido University School of Medicine

• Hosokawa Masuo

  Laboratory Of Pathology Cancer Institute Hokkaido University School Of Medicine

• Hosokawa Masuo

  Laboratories Of Pathology Cancer Institute Hokkaido University School Of Medicine

• Abe Hiroshi

  Department Of Neurosurgery University Of Hokkaido School Of Medicine

• Tada Mitsuhiro

  Department Of Chemistry Faculty Of Science Kochi University

• Sawamura Yutaka

  Department Of Neurosurgery University Of Hokkaido School Of Medicine

• Sawamura Yutaka

  Department Of Bioresource Science Faculty Of Agriculture Kagawa University

• Abe Hiroshi

  Department Of Anatomy Akita University School Of Medicine

• Suwamura Yutaka

  Department Of Neurosurgery Hokkaido University School Of Medicine

• Aida Toshimitsu

  Department Of Neurosurgery Hokkaido University School Of Medicine

• Kobayashi Hiroshi

  Laboratory Of Food Hygienic Chemistry Division Of Food Biotechnology Department Of Bioscience And Bi

• Abe Hiroshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

• Kobayashi Hiroshi

  Laboratory Of Pathology Cancer Institute Hokkaido University School Of Medicine

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