Restoration of T-Cell Depression and Suppression of Blood Pressure in Spontaneously Hypertensive Rats (SHR) by Allogeneic Thymus Grafts or Injection of Thymic Hormone
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概要
- 論文の詳細を見る
Experimental results demonstrate that allogeneic thymus graft completely restored the immune functions in the T-cell depressed SHR as detected by a rosette forming test, plaque forming assay and blastogenesis, and lowered titers of NTA in the serum of SHR. Injection of TS had less effects to immune functions and NTA titers. The relationship between T-cell depression and hypertension of SHR is not clear yet. However, allogeneic thymus grafts significantly suppressed hypertension of SHR from 2 weeks after grafts. Injections of TS prevented the development of hypertension in SHR. These results suggest that immunological abnormality may be related to development of hypertension in SHR.
- International Heart Journal刊行会の論文
著者
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Takeichi Noritoshi
Laboratory Of Cell Biology Cancer Institute
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Kobayashi Hiroshi
Laboratory Of Food Hygienic Chemistry Division Of Food Biotechnology Department Of Bioscience And Bi
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Ba Denian
Laboraoty of Pathology, Cancer Institute, Hokkaido University School of Medicine
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