Natural Cytotoxic Autoantibody Against Thymocytes in Spontaneously Hyper tensive Rats
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概要
- 論文の詳細を見る
Spontaneous hypertensive rats produced a natural thymocytotoxic autoantibody (NTA) which was cytotoxic for the thymocytes of the various strains of rats tested. More than a 60% incidence of NTA in the SHR occurred from 1 month of age and was observed throughout their life span. The titers of the autoantibody varied among individual rats and progressively increased with age. The NTA was cytotoxic for thymocytes but weak or negative for spleen, lymph node and bone marrow cells. However, absorption test indicated that NTA-reactive antigens were distributed in the thymus, spleen, lymph nodes, and brain of adult rats. The NTA in SHR was an IgM-globulin as determined by sensitivity to 2-ME treatment and by Sephadex G-200 column chromatography. These results suggest that the NTA is responsible for the selective suppression of T-cell functions in SHR.
- International Heart Journal刊行会の論文
著者
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Takeichi Noritoshi
Laboratory Of Cell Biology Cancer Institute
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Kobayashi Hiroshi
Laboratory Of Food Hygienic Chemistry Division Of Food Biotechnology Department Of Bioscience And Bi
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Ba Denian
Laboraoty of Pathology, Cancer Institute, Hokkaido University School of Medicine
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