Arrest of T-cell Maturation in Spontaneously Hypertensive Rats Associated with Deficiency of Thymic Hormone
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概要
- 論文の詳細を見る
The present study seeks to define the pathogenesis of T-cell depression in SHR. Thymus weights of SHR did not differ from those of age-matched W rats and histological changes were not observed until the rats were 6 months old. However, SHR thymus cells showed lower sensitivity to anti-thy 1.1 and anti-T sera when compared to those of W rats. These results suggest that SHR thymus may be composed of increased numbers of immature or extra thymic T-cells and of decreased numbers of relatively mature intrathymic T-cells. Because SHR thymus grafts failed to promote T-cell numbers and functions in nude mice, whereas W thymus grafts sufficiently restored them, the indication is that deficiency of thymic hormone produced by thymic epithelium may occur and may lead to an abnormal state of thymocyte differentiation.
- International Heart Journal刊行会の論文
著者
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Hosokawa Masuo
Laboratories Of Pathology Cancer Institute Hokkaido University School Of Medicine
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Suzuki Kazufumi
Laboratory Of Molecular Medicine Institute Of Medical Science University Of Tokyo
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Takeichi Noritoshi
Laboratory Of Cell Biology Cancer Institute
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Kobayashi Hiroshi
Laboratory Of Food Hygienic Chemistry Division Of Food Biotechnology Department Of Bioscience And Bi
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Ba Denian
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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Suzuki Kazufumi
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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Ba Denian
Laboraoty of Pathology, Cancer Institute, Hokkaido University School of Medicine
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