Immunological Suppression of Carcinogenesis in T-cell Depressed SHR
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概要
- 論文の詳細を見る
The results presented here show that the tumor incidence in T-cell depressed SHR after injection of MCA was higher than that in WKA rats with normal T-cell function. The depression of T-cell functions in SHR was almost completely restored by allogeneic thymus grafts or injection of NSP. At the same time, the generation of Killer T-cells was induced, and the activity of NK cells against K-562 cells was enhanced. The tumor incidence was suppressed and average latency periods were also prolonged in SHR grafted with WKA thymuses. The administration of NSP was effective in prolonging latency periods for the development of tumors. From these results, we suggest that the SHR is a suitable animal model for the investigation of the role of cell-mediated immunity in carcinogenesis.
- International Heart Journal刊行会の論文
著者
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Takeichi Noritoshi
Laboratory Of Cell Biology Cancer Institute
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Kobayashi Hiroshi
Laboratory Of Food Hygienic Chemistry Division Of Food Biotechnology Department Of Bioscience And Bi
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Ba Denian
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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Koga Yutaka
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine
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Ba Denian
Laboraoty of Pathology, Cancer Institute, Hokkaido University School of Medicine
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