Chromosome Aberrations and Sister Chromatid Exchanges Induced by Tryptophan Pyrolysates, Trp-P-1 and Trp-P-2, in Cultured Human and Chinese Hamster Cells

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概要

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• The frequencies of chromosome aberrations and sister chromatid exchanges (SCEs) were investigated in cultured human and Chinese hamster cells under the exposure to synthetic amino-γ-carboline derivatives, Trp-P-1 and Trp-P-2, without application of any exogenous metabolic activation system. Both compounds were found to induce chromosome aberrations and SCEs in PHA-stimulated human lymphocytes, Chinese hamster Don-6 and B-131 cells. In the human fibroblastic cell line, however, Trp-P-1 only induced SCEs, while Trp-P-2 induced neither aberrations nor SCEs.

• 日本学士院の論文

著者

• SASAKI MOTOMICHI

  Chromosome Research Unit, Faculty of Science, Hokkaido University

• YOSHIDA Mitsuaki

  Chromosome Research Unit, Faculty of Science, Hokkaido University

• SUGIMURA Keiko

  Chromosome Research Unit, Faculty of Science, Hokkaido University

• KAWACHI Takashi

  National Cancer Center Research Institute

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• A complex translocation involving chromosomes 1,8, and 21 in acute myeloblastic leukemia.
• Chromosome Aberrations and Sister Chromatid Exchanges Induced by Tryptophan Pyrolysates, Trp-P-1 and Trp-P-2, in Cultured Human and Chinese Hamster Cells

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