Clonal origin of Ph1-positive cells in a case of 46,XX/47,XXX/48,XXXX mosaicism associated with chronic myelocytic leukemia.

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概要

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• A 44-year-old female diagnosed as having chronic myelogenous leukemia (CML) in the acute phase is found to possess three cell lines, 46, XX (35%), 47, XXX (50%), and 48, XXXX (15%), in cultured lymphocytes, although her skin culture shows exclusively a 47, XXX karyotype. By contrast, all of the bone marrow cells examined in the acute phase as well as in remission and relapse has a 47, XXX, t(9;22) constitution, with some random karyotypic variations in the initial acute phase before therapy. These findings seem to provide additional evidence for the monoclonal origin of Ph1-positive cells in CML.

著者

• SASAKI MOTOMICHI

  Chromosome Research Unit, Faculty of Science, Hokkaido University

• NISHIHIRA Jun

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• YAMADA Toshiyuki

  Chromosome Research Unit, Faculty of Science, Hokkaido University

• SAKURAMA Shoki

  Second Department of Internal Medicine, Hokkaido University School of Medicine

• NAKAGAWA Shoichi

  Second Department of Internal Medicine, Hokkaido University School of Medicine

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