50.ABA合成類縁体による病害抵抗性抑制と構造活性相関(口頭発表)

概要

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When plants are infected by pathogens, systemic acquired resistance (SAR), which confers enhanced resistance against subsequent attack by a broad range of pathogens, is activated through the increase of salicylic acid (SA). To clarify the mechanisms underlying this system using chemical biology technique, we have established a high-throughput system for the easy identification of chemicals affecting SAR. Recently, it has been reported that abscisic acid (ABA) acts as a negative regulator of SA-mediated defense response. To elucidate the antagonistic interactions between plant disease resistance and ABA signaling pathway in detail, we examined the relationships between the structure of various ABA analogues and their inhibitory effects on plant disease resistance. The structureactivity relationships in our systems were mostly similar to those in conventional ABA bioassays (such as inhibitory effects on stomatal opening, α-amylase induction, seed germination and seedling elongation), but some of analogues move out of these relationships. Considering that more than ten ABA receptors were reported in Arabidopsis, we assume that specific ABA receptor(s), which have different agonist selectivity from other receptors, might function in the inhibition of SA-mediated defense response.
2010-10-01