29.ストリゴラクトンによるシロイヌナズナ胚軸徒長阻害活性の構造要求性(口頭発表)

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Strigolactones (SLs) or their metabolites act as endogenous inhibitors of axillary bud outgrowth. SLs induce seed germination not only parasitic weed seeds but also some dicot seeds, and inhibit hypocotyl elongation in Arabidopsis thaliana. We have been evaluated structural requirements for inhibition on hypocotyl elongation using structural analogs of SL. Synthetic SL, GR24, inhibited hypocotyl elongation with dose-dependence in Arabidopsis seedlings germinated in the dark, whereas the tricyclic lactone and the hydroxy methylfuranone little exhibited the inhibition. This results show the significance of the core structure of SL (a tricyclic lactone connected with a methylfuranone via an enol ether bridge) on inhibition of hypocotyl elongation in Arabidopsis seedlings. In tested compounds, GR24 was the most effective inhibitor. The C ring-modified compounds were weaker inhibitors than GR24, which act as an effective bud outgrowth inhibitor of rice d10 mutant. In our assay, GR24 also inhibit hypocotyl elongation in Arabidopsis max2 and max3 mutants. These results imply that the inhibition of hypocotyl elongation will mediate a new signal transduction pathway of SL.
2010-10-01