40. ジャスモン酸生合成阻害剤の光学分割と活性

概要

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Jasmonic acid (JA) is a signaling molecule that regulates a broad range of plant defense responses against herbivores and some microbial pathogens. Both the biosynthesis and the action of JA are important to JA signal transduction pathway. We have been working on the design and synthesis of specific inhibitors of JA biosynthesis. In the previous work, we reported that (R, S)-8-[1-(2, 4-dichlorophenyl)-2-imidazolyethoxy] octanoic acid heptyl ester (JM-8686) exhibits potent inhibitory activity against allene oxide synthase, a key enzyme in the biosynthetic pathway of JA. In this work, we report the optical rusolution of racemic JM-8686 by chiral high-performance liquid chromatography. The inhibitory activity of each stereoisomer against AOS was discussed.
植物化学調節学会の論文
2004-10-13