30.エノール骨格を持たないストリゴラクトン様活性化合物(口頭発表)

概要

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Strigolactone was found as a stimulant for parasitic weeds. Recent papers demonstrated that strigolactones induce hyphal branching in AM fungi and inhibit the outgrowth of axillary buds. Based on the chemical structure of strigolactones isolated from plants, such as strigol and orobanchol, several kinds of artifacts have been synthesized. Among them, GR24, GR7 and GR5 were known as analogues that show similar activity as natural strigolactones. These compounds have both D-ring and enol ether bond as common structural features. Recently we found that new compound 5-(4-Chlorophenoxy)-3-methylfuran-2(5H)-one (CPMF) interrupted brunching of rice d10 mutant as GR24, although CPMF does not have enol ether moiety in its molecule. We were very much interested in the structure of CPMF and started the structure-activity relationship study on CPMF. As a result, we found a new compound (BPMF) without enol ether moiety was 10 times more active than GR24. BPMF reduces the branching of both d10 mutant and max3 mutant of Arabidopsis to the level of wild type in the long-term test. Interestingly, these phenol ether type compounds did not promote the germination of O. minor.
2010-10-01